Closed-loop vagus nerve stimulation. Patient-tailored therapy or undirected treatment?
نویسندگان
چکیده
In multi-drug-resistant epilepsy vagus nerve stimulation (VNS) is an efficacious additional treatment to reduce seizure frequency and severity. A recently developed cardiac-based detection (CBSD) algorithm triggers automate (AutoStim) upon heart rate increases of at least 20%. Yet, long term sensitivity specificity the CBSD-algorithm remain unclear. We present a case series 15 adult patients with AutoStim VNS therapy. reviewed CBSD-settings, operating hours battery status devices. Percentage was assessed in comparison continuous but intermittent stimulation. If diaries were available, we verified whether high during documented seizures. mean age 34 years (±11y). Mean duration since implantation 47 months (±12 m). Of 1296 (±686) stimulations per week, 4.8 (±3.9)% AutoStim. Proportion varied substantially. While 9 had 1.5% (±1.4%), 6 significantly higher proportion 9.0% (±1.6%). Seizure-frequency frequency. Adverse events occurred none patients. provide long-term results for CBSD algorithm. seems be high, presume poor. An extremely number supposedly false-positive. well tolerated by without any adverse events, despite promising development, yet should revised better specificity.
منابع مشابه
Vagus nerve stimulation therapy
Over the past 5 years, and especially within the last year, there has been a rapid expansion of vagus nerve stimulation (VNS)-related preclinical research, as well as clinical studies in indications other than epilepsy. The research advances in understanding VNS are occurring in the midst of a blossoming of other forms of therapeutic brain stimulation, such as electroconvulsive therapy (ECT), t...
متن کامل[Vagus nerve stimulation therapy for epilepsy].
Vagus nerve stimulation is a palliative treatment for medically intractable epilepsy. This treatment reduces the frequency and severity of seizures refractory to antiepileptic drugs. Implanted generator and helical electrodes electrically stimulate the left vagus nerve at the neck chronically and intermittently. This was the first electrostimulation therapy clinically introduced for epilepsy. T...
متن کاملVagus nerve stimulation therapy for seizures.
Of the 3 million patients with seizures in North America approximately 70% have effective seizure control with medications. In the group refractory to medical treatment only a minority fit the criteria for surgical therapy. Vagus nerve stimulation therapy seems to be a suitable nonpharmacologic therapy for reducing seizure frequency in these cases. It is a simple device with 2 electrodes and an...
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ژورنال
عنوان ژورنال: Interdisciplinary Neurosurgery
سال: 2021
ISSN: ['2214-7519']
DOI: https://doi.org/10.1016/j.inat.2020.101003